1-((4-Methoxyphenyl)methyl)piperazine → 4-(4-Methoxy-benzyl)-piperazine-1-carboxylic Acid 4-(4,4-dimethyl-2,6-dioxo-piperidin-1-yl)-phenyl Ester

HRID 1179970

Reaction equation

HRID 1179970 reaction equation
Cl[C:2]([O:4][C:5]1[CH:10]=[CH:9][C:8]([N:11]2[C:16](=[O:17])[CH2:15][C:14]([CH3:19])([CH3:18])[CH2:13][C:12]2=[O:20])=[CH:7][CH:6]=1)=[O:3].[CH3:21][O:22][C:23]1[CH:35]=[CH:34][C:26]([CH2:27][N:28]2[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]2)=[CH:25][CH:24]=1>>[CH3:18][C:14]1([CH3:19])[CH2:15][C:16](=[O:17])[N:11]([C:8]2[CH:9]=[CH:10][C:5]([O:4][C:2]([N:31]3[CH2:30][CH2:29][N:28]([CH2:27][C:26]4[CH:34]=[CH:35][C:23]([O:22][CH3:21])=[CH:24][CH:25]=4)[CH2:33][CH2:32]3)=[O:3])=[CH:6][CH:7]=2)[C:12](=[O:20])[CH2:13]1

Participants

3

Reactant 2

HCID 2319051-((4-Methoxyphenyl)methyl)piperazineHCID 220478954-(4,4-Dimethyl-2,6-dioxo-piperidin-1-yl)-phenyl chloroformate

Product 1

HCID 574558374-(4-Methoxy-benzyl)-piperazine-1-carboxylic Acid 4-(4,4-dimethyl-2,6-dioxo-piperidin-1-yl)-phenyl Ester

Procedure

The title compound was prepared from 4-(4,4-dimethyl-2,6-dioxo-piperidin-1-yl)-phenyl chloroformate and 1-(4-methoxybenzyl)-piperazine, preparative HPLC (Method C) (54%, white crystals). HPLC-MS m/z=466.3 (M+1), Rt: 2.26 min.

Sources & evidence

ORD record
ord-e0029471ee6d40fc9b6386dc110dda75
Source dataset
uspto-grants-2007_10
Patent number
US07279470B2

Linked notes

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