Methyl 2-bromo-4-methylpentanoate → HCID 69472556, compound
Reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:10]2[S:11][CH:12]=[CH:13][N:14]=2)[OH:9])=[CH:4][CH:3]=1.Br[CH:16]([CH2:21][CH:22]([CH3:24])[CH3:23])[C:17]([O:19][CH3:20])=[O:18]>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([C:10]2[S:11][CH:12]=[CH:13][N:14]=2)[O:9][CH:16]([CH2:21][CH:22]([CH3:24])[CH3:23])[C:17]([O:19][CH3:20])=[O:18])=[CH:6][CH:7]=1Participants
3
Procedure
Using the same protocol as described in example 23, step 2, (4-bromophenyl)(1,3-thiazol-2-yl)methanol from step 1 (983 mg, 3.64 mmol) was added to methyl 2-bromo-4-methylpentanoate (624 μL, 3.82 mmol). The crude residue was chromatographed on silica gel using 25% ethyl acetate in hexanes to afford the title compound.
Workup
- customThe crude residue was chromatographed on silica gel using 25% ethyl acetate in hexanes
Sources & evidence
- ORD record
- ord-bfa3453ddb734985a328f0a4fafdaf5d