Br[C:2]1[N:3]=[CH:4][NH:5][CH:6]=1.[F:7][C:8]([F:19])([F:18])[C:9]1[CH:14]=[CH:13][C:12](B(O)O)=[CH:11][CH:10]=1.CC1(C)C(C)(C)OB([C:28]2[CH:29]=[CH:30][C:31]3[CH2:38][C@H:37]4[C@:39]5([CH2:43][N:42]([CH2:44][C:45]([F:48])([F:47])[F:46])[S:41](=[O:50])(=[O:49])[NH:40]5)[C@H:34]([CH2:35][CH2:36]4)[CH2:33][C:32]=3[CH:51]=2)O1>CS(C)=O>[F:7][C:8]([F:19])([F:18])[C:9]1[CH:14]=[CH:13][C:12]([N:5]2[CH:6]=[C:2]([C:28]3[CH:29]=[CH:30][C:31]4[CH2:38][C@H:37]5[C@:39]6([CH2:43][N:42]([CH2:44][C:45]([F:48])([F:47])[F:46])[S:41](=[O:49])(=[O:50])[NH:40]6)[C@H:34]([CH2:35][CH2:36]5)[CH2:33][C:32]=4[CH:51]=3)[N:3]=[CH:4]2)=[CH:11][CH:10]=1Prepared from 4-bromo-1H-imidazole, 4-(trifluoromethyl)phenylboronic acid and homochiral boronate from Example 24 Step 1 following the procedures in Example 76 Steps 1 and 2. δ (1H, 360 MHz, DMSO) 1.08-1.11 (2H, m), 1.67-1.75 (2H, m), 2.35-2.38 (2H, m), 2.56-2.70 (2H, m), 3.15-3.20 (2H, m), 3.46 (2H, s), 4.00-4.05 (2H, m), 7.15 (1H, d, J=7.2 Hz), 7.56-7.62 (2H, m), 7.90-8.05 (4H, m), 8.36 (1H, s), 8.49 (1H, s). MS (ES+) 571 ([MH]+).
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