Sulfuric Acid → HCID 178515316, compound

HRID 1181411Notes

Reaction equation

HRID 1181411 reaction equation
[Br:1][C:2]1[CH:18]=[CH:17][CH:16]=[CH:15][C:3]=1[CH2:4][NH:5][C:6](=[O:14])[CH:7](OCC)OCC.OS(O)(=O)=O>>[Br:1][C:2]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:3]=1[CH:4]=[N:5][C:6]([OH:14])=[CH:7]2

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 59636401N-(2-Bromobenzyl)-2,2-diethoxyacetamide

Product 1

HCID 178515316HCID 178515316, compoundYield 92%

Conditions

Temperature
15 °C

Procedure

N-(2-Bromobenzyl)-2,2-diethoxyacetamide (Description 52; 15.6 g, 49 mmol) was carefully added to concentrated H2SO4 (78 ml) with stirring at 10-20° C. The reaction mixture was stirred at room temperature for 16 hours, poured into ice water and filtered. The filtrate was neutralised with 33% aqueous ammonium hydroxide and the resulting precipitate was filtered and dried to give the title compound (10.1 g, 91%).

Workup

  1. stirringThe reaction mixture was stirred at room temperature for 16 hours
  2. filtrationfiltered
  3. filtrationthe resulting precipitate was filtered
  4. customdried

Sources & evidence

ORD record
ord-66aac32169c34533a7b23dd15a942d66
Source dataset
uspto-grants-2007_10
Patent number
US07285563B2

Reaction notes

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