4-Methylisoquinolin-5-amine → HCID 69523006, compound

Reaction equation

[CH3:1][C:2]1[C:11]2[C:10]([NH2:12])=[CH:9][CH:8]=[CH:7][C:6]=2[CH:5]=[N:4][CH:3]=1.[F:13][C:14]([F:26])([F:25])[C:15]1[CH:24]=[CH:23][C:18]([CH2:19][N:20]=[C:21]=[O:22])=[CH:17][CH:16]=1>>[CH3:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[NH:12][C:21]([NH:20][CH2:19][C:18]2[CH:17]=[CH:16][C:15]([C:14]([F:13])([F:26])[F:25])=[CH:24][CH:23]=2)=[O:22])[CH:5]=[N:4][CH:3]=1

Participants

Reactant 2

HCID 219799844-Methylisoquinolin-5-amine

HCID 223376994-(Trifluoromethyl)benzyl isocyanate

Product 1

HCID 69523006HCID 69523006, compound

Procedure

Prepared fiom 4-methylisoquinolin-5-amine (Description 91) and [4-(trifluoromethyl)benzyl]isocyanate (Description 58) according to Description 61. m/z (ES+) 360 (M+H)+.

Sources & evidence

ORD record: ord-ae884ed328f04216a7314d63340d15bf
Source dataset: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07285563B2

Reaction notes

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