Acetic Anhydride → 7-Methoxyisochroman-1,3-dione
Reaction equation
[O:1]([C:3]1[CH:4]=[C:5]([C:13]([OH:15])=[O:14])[C:6](=[CH:11][CH:12]=1)[CH2:7][C:8]([OH:10])=O)[CH3:2].C(OC(=O)C)(=O)C>C1(C)C=CC=CC=1>[O:1]([C:3]1[CH:4]=[C:5]2[C:13](=[O:14])[O:15][C:8](=[O:10])[CH2:7][C:6]2=[CH:11][CH:12]=1)[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
1.1 g (5.2 mmol) of 4-methoxylhomophthalic acid (IIb) was dissolved in 20 ml toluene, and 0.7 ml (7.9 mmol) of acetic anhydride was added. The mixture was heated to the reflux temperature and reacted for 0.5 h. Then, the reaction mixture was cooled to the room temperature and concentrated to dry in a reduced pressure to obtain 1.1 g of a pale yellow solid with the yield of 100%. m.p. 142-143° C.
Workup
- temperatureThe mixture was heated to the reflux temperature
- customreacted for 0.5 h
- concentrationconcentrated
- customto dry in a reduced pressure
Sources & evidence
- ORD record
- ord-0e854e3c0041495d83017d510ade7a4a
- Source dataset
- uspto-grants-2014_03
- Patent number
- US08664238B2
Reaction notes
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