1-Boc-3-hydroxypiperidine → Tert-butyl 3-[3-[1-(4-cyanoanilino)-2-ethoxy-2-oxoethyl]-5-ethoxy-2-fluorophenoxy]piperidine-1-carboxylate

HRID 118318

Reaction equation

HRID 118318 reaction equation
[C:27]([CH3:28])([CH3:29])([CH3:30])[O:31][C:32](=[O:33])[N:34]1[CH2:35][CH:36]([OH:40])[CH2:37][CH2:38][CH2:39]1.[CH2:1]([CH3:2])[O:3][C:4]([CH:5]([c:6]1[c:7]([F:16])[c:8]([OH:15])[cH:9][c:10]([O:12][CH2:13][CH3:14])[cH:11]1)[NH:17][c:18]1[cH:19][cH:20][c:21]([C:24]#[N:25])[cH:22][cH:23]1)=[O:26]>>[CH2:1]([CH3:2])[O:3][C:4]([CH:5]([c:6]1[c:7]([F:16])[c:8]([O:15][CH:36]2[CH2:35][N:34]([C:32]([O:31][C:27]([CH3:28])([CH3:29])[CH3:30])=[O:33])[CH2:39][CH2:38][CH2:37]2)[cH:9][c:10]([O:12][CH2:13][CH3:14])[cH:11]1)[NH:17][c:18]1[cH:19][cH:20][c:21]([C:24]#[N:25])[cH:22][cH:23]1)=[O:26]

Participants

3

Reactant 2

HCID 5456991-Boc-3-hydroxypiperidineHCID 69924374(RS)-(4-cyano-phenylamino)-(5-ethoxy-2-fluoro-3-hydroxy-phenyl)-acetic acid ethyl ester

Product 1

HCID 70005138Tert-butyl 3-[3-[1-(4-cyanoanilino)-2-ethoxy-2-oxoethyl]-5-ethoxy-2-fluorophenoxy]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-baa5e59d7b5a4c68b664231e39acb03a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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