4-Methyl-m-anisic acid → Benzoic acid, 3-methoxy-4-methyl-, methyl ester

Reaction equation

[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[CH3:12])[C:6]([OH:8])=[O:7].Cl[C:14]1C=C(C=CC=1CC(C1C=CC(O)=CC=1O)=O)C(OC)=O>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][C:11]=1[CH3:12])[C:6]([O:8][CH3:14])=[O:7]

Participants

Reactant 2

HCID 815794-Methyl-m-anisic acid

HCID 67365584Methyl 3-chloro-4-(2-(2,4-dihydroxyphenyl)-2-oxoethyl)benzoate

Product 1

HCID 591123Benzoic acid, 3-methoxy-4-methyl-, methyl ester

Procedure

starting with 3-methoxy-4-methylbenzoic acid (see step 1 of Intermediate F). MS (ESI): m/z 181.1 [M+1]+.

Sources & evidence

ORD record: ord-5a8ebf71c8e84035948381425f027461
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08669381B2

Reaction notes

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