7-chloro-1H-indazole → HCID 66597907, compound

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][N:8]=[CH:7]2.ClC1C=CC=C2C=1N([CH2:21][CH2:22][C:23]#[C:24][Si:25]([CH3:28])([CH3:27])[CH3:26])N=C2>>[Cl:1][C:2]1[C:10]2[C:6](=[CH:7][N:8]([CH2:21][CH2:22][C:23]#[C:24][Si:25]([CH3:28])([CH3:27])[CH3:26])[N:9]=2)[CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 111162497-chloro-1H-indazole

HCID 66598304HCID 66598304, compound

Product 1

HCID 66597907HCID 66597907, compoundYield 63%

Procedure

The title compounds were prepared in accordance with the general method of Example 108(A), from 7-chloro-1H-indazole (220 mg, 1.44 mmol) to yield 250 mg (0.90 mmol, 63%) of 7-chloro-2-(4-trimethylsilanyl-but-3-ynyl)-2H-indazole and 7-chloro-1-(4-trimethylsilanyl-but-3-ynyl)-1H-indazole.

Sources & evidence

ORD record: ord-f6d6ad7ad678495ba7366f6cac4c72f9
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08674106B2

Reaction notes

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