1-Cyclohexenylboronic acid → HCID 58994521, compound

Reaction equation

Br[C:2]1[CH:7]=[C:6]([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)[CH:5]=[CH:4][C:3]=1[NH2:16].[C:17]1(B(O)O)[CH2:22][CH2:21][CH2:20][CH2:19][CH:18]=1>>[C:17]1([C:2]2[CH:7]=[C:6]([CH2:8][CH2:9][N:10]3[CH2:15][CH2:14][O:13][CH2:12][CH2:11]3)[CH:5]=[CH:4][C:3]=2[NH2:16])[CH2:22][CH2:21][CH2:20][CH2:19][CH:18]=1

Participants

Reactant 2

HCID 38629021-Cyclohexenylboronic acid

HCID 589944272-Bromo-4-(2-morpholin-4-yl-ethyl)-phenylamine

Product 1

HCID 58994521HCID 58994521, compound

Procedure

This compound is prepared by Suzuki coupling of 2-bromo-4-(2-morpholin-4-yl-ethyl)-phenylamine (as prepared in the previous step) and 1-cyclohexen-1-yl-boronic acid according to the procedure in Example 1, step (e). Mass spectrum (ESI, m/z): Calcd. for C18H26N2O, 287.2 (M+H). found 287.0.

Sources & evidence

ORD record: ord-05585994cbfa49b48b45d4bf3aedf477
Source dataset: uspto-grants-2014_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08674100B2

Reaction notes

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