2-Chloro-4,5,6-trimethylpyrimidine → (1R,6S)-8-(4,5,6-Trimethylpyrimidin-2-yl)-3,8-diazabicyclo[4.2.0]octane
Reaction equation
CC1N=C([N:8]2[C@@H:15]3[C@@H:10]([CH2:11][CH2:12][NH:13][CH2:14]3)[CH2:9]2)C=CC=1.Cl[C:17]1[N:22]=[C:21]([CH3:23])[C:20]([CH3:24])=[C:19]([CH3:25])[N:18]=1.[C@@H]12NC[C@@H]1CCN(C(OC(C)(C)C)=O)C2>>[CH3:25][C:19]1[C:20]([CH3:24])=[C:21]([CH3:23])[N:22]=[C:17]([N:8]2[C@@H:15]3[C@@H:10]([CH2:11][CH2:12][NH:13][CH2:14]3)[CH2:9]2)[N:18]=1Participants
4
Procedure
(1R,6S)-8-(4,5,6-Trimethylpyrimidin-2-yl)-3,8-diazabicyclo[4.2.0]octane was prepared in a manner analogous to Intermediate 40, using Intermediate 66 and Intermediate 39 as starting materials. MS (ESI) mass calcd. for C13H20N4, 232.17; m/z found, 233.1 [M+H]+.