Imidazole → 3-(1H-Imidazol-1-yl)-1-(1H-indol-3-yl)propan-1-one

Reaction equation

[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]([C:10](=[O:13])[CH:11]=[CH2:12])=[CH:2]1.[NH:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>>[N:14]1([CH2:12][CH2:11][C:10]([C:3]2[C:4]3[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=3)[NH:1][CH:2]=2)=[O:13])[CH:18]=[CH:17][N:16]=[CH:15]1

Participants

Reactant 2

HCID 795Imidazole

HCID 15122794HCID 15122794, compound

Product 1

HCID 212700593-(1H-Imidazol-1-yl)-1-(1H-indol-3-yl)propan-1-oneYield 56.2%

Procedure

By a similar procedure to that described in Example 1, 1-(1H-indol-3-yl)-1-prop-2-enone (0.4 g) was reacted with imidazole (0.8 g) to give the title compound (0.314 g), m.p. 194°-197°; λmax (EtOH) 242.5 nm (ε12,900) λinf 259 nm (ε9,090) λmax 299.5 nm (ε12,390).

Sources & evidence

ORD record: ord-31532b70e2fc45128b535801b8deded3
Source dataset: uspto-grants-1989_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04814344

Reaction notes

Loading…