(R)-(+)-1,1,1-trifluoro-2-octyl 4-benzyloxybenzoate → 4-hydroxybenzoic acid (R)-1-trifluoromethyl-heptyl ester

HRID 1195092

Reaction equation

HRID 1195092 reaction equation
[F:1][C:2]([F:28])([F:27])[C@H:3]([O:10][C:11](=[O:26])[C:12]1[CH:17]=[CH:16][C:15]([O:18]CC2C=CC=CC=2)=[CH:14][CH:13]=1)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9].[H][H]>[Pd].C(O)C>[F:1][C:2]([F:27])([F:28])[C@H:3]([O:10][C:11](=[O:26])[C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1)[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH3:9]

Participants

5

Reactant 2

HCID 22850730(R)-(+)-1,1,1-trifluoro-2-octyl 4-benzyloxybenzoateHCID 178418361HCID 178418361, compound

Product 1

HCID 145492174-hydroxybenzoic acid (R)-1-trifluoromethyl-heptyl ester

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

The resulting ester compound and 0.13 g of 10% palladium-on-carbon were added to ethanol to conduct debenzylation in a hydrogen atmosphere to obtain 0.39 g of (R)-(+)-4-hydroxybenzoic acid 1-trifluoromethylheptyl ester ##STR7##

Sources & evidence

ORD record
ord-21036450c4914879a77787c2a5666200
Source dataset
uspto-grants-1992_05
Patent number
US05110497

Linked notes

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