HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Carbobenzoxy-tyrosyl-glycyl-glycine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Glycylglycine | HCID 11163 | — |
| Reactant | N-[(Phenylmethoxy)carbonyl]-L-tyrosine methyl ester | HCID 7010613 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Carbobenzoxy-tyrosyl-glycyl-glycine | HCID 15024388 | — |
Reaction Steps
330 mg (1 mmole) of Z-L-Tyr-OMe, 400 mg (2.2 mmole) of H-Gly-Gly-Ome, HCl were suspended in 5 mL DMSO and 5 mL 0.1 M tris-HCl, pH 8.9. 25 mg of α-chymotrypsin were added and the reaction stirred for 30 minutes. Five volumes of ice water were added, and the precipitate collected by filtration. Yield 312 mg (70%, based on acyl-donor). Amino acid analysis: tyr1.0,gly2.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05116741 |
| Source dataset | uspto-grants-1992_05 |
| ORD ID | ord-3045a12175474c26a96874021fff6f5d |
| Source note | uspto-grants-1992_05 |