N-Formylmethionine → 6,9-Difluoro-21-[2-(formylamino)-4-methylthio-1-oxobutylthio]-11alpha,17-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione
Reaction equation
[F:1][CH:2]1[C:22]2[C@:17]([CH3:24])([CH:18]=[CH:19][C:20](=[O:23])[CH:21]=2)[C@:16]2([F:25])[C@H:4]([C@H:5]3[C@:13]([CH3:27])([CH2:14][C@@H:15]2[OH:26])[C@@:8]([OH:28])([C:9](=[O:12])[CH2:10][SH:11])[C@@H:7]([CH3:29])[CH2:6]3)[CH2:3]1.[CH:30]([NH:32][C@H:33]([C:38](O)=[O:39])[CH2:34][CH2:35][S:36][CH3:37])=[O:31]>>[F:1][CH:2]1[C:22]2[C@:17]([CH3:24])([CH:18]=[CH:19][C:20](=[O:23])[CH:21]=2)[C@:16]2([F:25])[C@H:4]([C@H:5]3[C@:13]([CH3:27])([CH2:14][C@H:15]2[OH:26])[C@@:8]([OH:28])([C:9](=[O:12])[CH2:10][S:11][C:38](=[O:39])[CH:33]([NH:32][CH:30]=[O:31])[CH2:34][CH2:35][S:36][CH3:37])[C@H:7]([CH3:29])[CH2:6]3)[CH2:3]1Participants
3
Procedure
The title compound (0.027 gm) was prepared from 6,9-difluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione-21-thiol (0.06 gm) and (N-formyl-L-methionine (0.175 gm) in the same manner as in Synthetic Example 1.