2-Hydrazinyl-3-(propan-2-yl)-5-(pyridin-3-yl)pyrazine → HCID 178471157, compound
Reaction equation
[NH:1]([C:3]1[C:8]([CH:9]([CH3:11])[CH3:10])=[N:7][C:6]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[CH:5][N:4]=1)[NH2:2].[NH:18]1[CH:22]=[C:21]([CH2:23][CH:24]([C:30](OCC)=O)[C:25]([O:27][CH2:28][CH3:29])=[O:26])[N:20]=[CH:19]1>>[CH:9]([C:8]1[C:3]2[N:4]([C:30]([CH:24]([CH2:23][C:21]3[N:20]=[CH:19][NH:18][CH:22]=3)[C:25]([O:27][CH2:28][CH3:29])=[O:26])=[N:2][N:1]=2)[CH:5]=[C:6]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[N:7]=1)([CH3:11])[CH3:10]Participants
3
Procedure
In a manner analogous to Example 1, by condensing 2-hydrazino-3-isopropyl-5-(3-pyridyl)pyrazine with diethyl (imidazol-4-ylmethyl)malonate there is obtained ethyl rac-8-isopropyl-α-(imidazol-4-ylmethyl)-6-(3-pyridyl)-s-triazolo[4,3-a]pyrazine-3-acetate, MS: 405 (M)+, which is converted into the above acid by alkaline saponification.
Sources & evidence
- ORD record
- ord-845945f5038348168122aec9507829be
- Source dataset
- uspto-grants-1994_01