(E)-3-(1H-Indol-7-yl)acrylonitrile → 3-(1H-Indol-7-YL)propanenitrile

HRID 1198536Notes

Reaction equation

HRID 1198536 reaction equation
[C:1](/[CH:3]=[CH:4]/[C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:13]=1[NH:12][CH:11]=[CH:10]2)#[N:2]>C(O)C.[Pd]>[C:1]([CH2:3][CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[C:9]2[C:13]=1[NH:12][CH:11]=[CH:10]2)#[N:2]

Participants

4

Reactant 1

HCID 19959103(E)-3-(1H-Indol-7-yl)acrylonitrile

Product 1

HCID 199591053-(1H-Indol-7-YL)propanenitrile

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 7-[2-(E)-cyanoethenyl]indole (0.28 g) in ethanol (75 ml) was hydrogenated at 50 psi over 10% palladium on charcoal (0.1 g) for 4 hours. The catalyst was filtered off and the filtrate was evaporated to give the product.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate was evaporated
  3. customto give the product

Sources & evidence

ORD record
ord-0f8edb9087e34736b4582c2d32ffe841
Source dataset
uspto-grants-1994_01
Patent number
US05281593

Reaction notes

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