HCID 19867235, compound → HCID 19867190, compound

Reaction equation

BrC1C=CC(C2C=CC(CCC=O)=CN=2)=CC=1.[Br:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]2[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][CH:33]=[CH:34][O:35]C)=[CH:27][N:26]=2)=[CH:21][CH:20]=1>>[Br:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]2[CH:30]=[CH:29][C:28]([CH2:31][CH2:32][CH2:33][CH:34]=[O:35])=[CH:27][N:26]=2)=[CH:23][CH:24]=1

Participants

Reactant 2

HCID 19867235HCID 19867235, compound

HCID 54500502HCID 54500502, compound

Product 1

HCID 19867190HCID 19867190, compound

Procedure

3-[2-(p-Bromophenyl)-5-pyridyl]propionaldehyde is converted in an analogous manner to paragraph (a) into 2-(p-bromophenyl)-5-(4-methoxy-3-butenyl)pyridine and this is then hydrolyzed in an analogous manner to paragraph (b) to give 4-[2-(p-bromophenyl)-5-pyridyl]butyraldehyde.

Sources & evidence

ORD record: ord-7a83982ca4414eaba391696294232f69
Source dataset: uspto-grants-1990_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04898455

Reaction notes

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