Formaldehyde → HCID 14519538, compound
Reaction equation
[CH2:1]([O:3][C:4](=[O:17])[CH2:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9](=[O:16])[NH:8][N:7]=1)[CH3:2].[CH2:18]=[O:19]>C(O)C>[CH2:1]([O:3][C:4](=[O:17])[CH2:5][C:6]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[C:9](=[O:16])[N:8]([CH2:18][OH:19])[N:7]=1)[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of ethyl-4-oxo-3-H-phthalazin-1-ylacetate (23.42 g), ethanol (200 ml) and aqueous formaldehyde (37% concentration, 100 ml) was refluxed for 40 hours. This solution was concentrated to 100 ml and was then poured onto ice water (750 ml). The precipitated solid was collected and air-dried (yield: 17.1 g; m.p. 113°-114° C.).
Workup
- temperaturewas refluxed for 40 hours
- concentrationThis solution was concentrated to 100 ml
- additionwas then poured onto ice water (750 ml)
- customThe precipitated solid was collected
- customair-dried (yield: 17.1 g; m.p. 113°-114° C.)
Sources & evidence
- ORD record
- ord-c490b7fc750e4eaab3ad41c3c0285160
- Source dataset
- uspto-grants-1990_02
- Patent number
- US04900844
Reaction notes
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