Hydrogen Sulfide → 4,6-Dimethylpyrimidin-2-ylthiourea

HRID 1199902

Reaction equation

HRID 1199902 reaction equation
[C:1]([NH:3][C:4]1[N:9]=[C:8]([CH3:10])[CH:7]=[C:6]([CH3:11])[N:5]=1)#[N:2].[SH2:12].C(Cl)Cl>N1C=CC=CC=1>[CH3:10][C:8]1[CH:7]=[C:6]([CH3:11])[N:5]=[C:4]([NH:3][C:1]([NH2:2])=[S:12])[N:9]=1

Participants

5

Reactant 3

HCID 402Hydrogen Sulfide2×HCID 6344DichloromethaneHCID 521618(4,6-Dimethylpyrimidin-2-yl)cyanamide

Product 1

HCID 7475004,6-Dimethylpyrimidin-2-ylthiourea

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A suspension of 10 g of 2-cyanoamino-4,6-dimethylpyrimidine in 50 ml of pyridine was saturated with hydrogen sulfide and stored for 1 hour at 25°. The H2S treatment was repeated twice more, and the mixture was allowed to stir at 25° for 16 hours. Methylene chloride was added, and the product was filtered and washed with methylene chloride to afford 8 g of 4,6-dimethylpyrimidin-2-yl thiourea, m.p. >260°. IR (Nujol) 3280, 3180, 3120, 1610 cm-1.

Workup

  1. filtrationthe product was filtered
  2. washwashed with methylene chloride

Sources & evidence

ORD record
ord-96f5c4c8ef3842fb955baf33b021b241
Source dataset
uspto-grants-1990_02
Patent number
US04904299

Linked notes

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