Ammonia → HCID 70357192, compound
Reaction equation
O=[C:2]([CH3:21])[CH2:3][C:4]([O:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[C:19]2[CH:18]=[CH:17][N:16]=[CH:15][C:14]=2[N:13]=[C:12]1[CH3:20])=[O:5].[NH3:22]>C(O)C>[NH2:22][C:2]([CH3:21])=[CH:3][C:4]([O:6][CH2:7][CH2:8][CH2:9][CH2:10][N:11]1[C:19]2[CH:18]=[CH:17][N:16]=[CH:15][C:14]=2[N:13]=[C:12]1[CH3:20])=[O:5]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
4-(2-Methylimidazo[4,5-c]pyrid-1-yl)butyl 3-oxobutanoate (1.52 g) (see Preparation 6) was dissolved in ethanol (50 ml) containing dry silica gel (2.5 g) and gaseous ammonia was then bubbled through the mixture for 20 minutes. The mixture was stirred at room temperature for a further 11/2 hours and then filtered and evaporated to dryness leaving the crude title compound (1.54 g) which was used directly.