Methanol → Methyl 4-chloro-3-hydroxy-5-methoxythiophene-2-carboxylate

Reaction equation

Cl[C:2]1([C:9]([O:11][CH3:12])=[O:10])[C:6](=[O:7])[C:5]([Cl:8])=[CH:4][S:3]1.[CH3:13][OH:14]>>[Cl:8][C:5]1[C:6]([OH:7])=[C:2]([C:9]([O:11][CH3:12])=[O:10])[S:3][C:4]=1[O:14][CH3:13]

Participants

Reactant 2

HCID 887Methanol

HCID 15588103HCID 15588103, compound

Product 1

HCID 54706805Methyl 4-chloro-3-hydroxy-5-methoxythiophene-2-carboxylate

Procedure

2,4-Dichloro-2-methoxycarbonylthiophene-3(2H)-one (10 mmol) was stirred in anhydrous methanol at room temperature for 4 hours and the precipitate filtered, m.p. 109°-111° C. (methanol).

Workup

filtrationthe precipitate filtered

Sources & evidence

ORD record: ord-18e31df2196e40d6bcef398aa14201e1
Source dataset: uspto-grants-1990_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04904686

Reaction notes

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