(+-)-Pantolactone → Keto-pantoyllactone

HRID 1200267Notes

Reaction equation

HRID 1200267 reaction equation
[CH3:1][C:2]1([CH3:9])[CH:7]([OH:8])[C:5](=[O:6])[O:4][CH2:3]1>[O-2].[Fe+3].[O-2].[O-2].[Fe+3].[Mo](=O)(=O)=O>[CH3:1][C:2]1([CH3:9])[C:7](=[O:8])[C:5](=[O:6])[O:4][CH2:3]1

Participants

4

Reactant 1

HCID 989(+-)-Pantolactone2×

Product 1

HCID 39Keto-pantoyllactone

Reagents, catalysts & solvents 2

HCID 14802Molybdenum trioxideCatalystHCID 14833Hematite (Fe2O3)Catalyst

Procedure

A mixture of iron (III) oxide and molybdenum trioxide (G-105 from Girdler) is used as the catalyst in the reactor described in Example 1 and the temperature of the air bath is adjusted to 225° C. 60 l of air and 33 g of pantolactone are subsequently added hourly to the evaporator. 96% of the pantolactone are transformed and ketopantolactone is formed with a selectivity of 83%.

Workup

  1. customis adjusted to 225° C

Sources & evidence

ORD record
ord-c781faa2b1a44c349a9a32b4dad84e85
Source dataset
uspto-grants-1990_02
Patent number
US04904805

Reaction notes

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