Bicarbonate Ion → 2-(Chloromethyl)-3-fluoropyridine

Reaction equation

[C:14](=[O:15])([OH:16])[O-:17].[Cl:19][CH2:20][Cl:21].[F:1][c:2]1[c:3]([CH2:8][OH:9])[n:4][cH:5][cH:6][cH:7]1.[Na+:18].[S:10]([Cl:11])([Cl:12])=[O:13]>>[F:1][c:2]1[c:3]([CH2:8][Cl:12])[n:4][cH:5][cH:6][cH:7]1

Participants

Reactant 5

HCID 769Bicarbonate Ion

HCID 923Sodium Ion

HCID 6344Dichloromethane

HCID 24386Thionyl Chloride

HCID 19703803(3-Fluoropyridin-2-yl)methanol

Product 1

HCID 151336022-(Chloromethyl)-3-fluoropyridine

Sources & evidence

ORD record: ord-f0dd4aca00dc412d916724fb2c70e3fc
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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