Methanol → 4-(3-Phenylpropyl)piperidin-4-ol

Reaction equation

[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][C:11]([CH2:14][CH2:15][CH2:16][c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)([OH:23])[CH2:12][CH2:13]1.[CH3:24][OH:25].[OH-:26].[OH-:27].[Pd+2:28]>>[NH:8]1[CH2:9][CH2:10][C:11]([CH2:14][CH2:15][CH2:16][c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)([OH:23])[CH2:12][CH2:13]1

Participants

Reactant 4

HCID 887Methanol

HCID 961Hydroxide2×

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 226244781-Benzyl-4-(3-phenylpropyl)piperidin-4-ol

Product 1

HCID 4169034-(3-Phenylpropyl)piperidin-4-ol

Sources & evidence

ORD record: ord-5c347643f4384dfcae15c94e6493d0ec
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (2/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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