Isobutyl iodide → 2-Isobutyl-2-methyl-cyclohexanone

Reaction equation

[CH3:1][CH:2]1[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=[O:8].I[CH2:10][CH:11]([CH3:13])[CH3:12].CC1(C)CCCCC1=O>>[CH2:10]([C:2]1([CH3:1])[CH2:7][CH2:6][CH2:5][CH2:4][C:3]1=[O:8])[CH:11]([CH3:13])[CH3:12]

Participants

Reactant 3

HCID 10556Isobutyl iodide

HCID 114192-Methylcyclohexanone

HCID 1369292,2-Dimethylcyclohexan-1-one

Product 1

HCID 686799792-Isobutyl-2-methyl-cyclohexanone

Procedure

The alkylation of 2-methylcyclohexanone with 1-iodo-2-methyl-propane takes place in a manner similar to that described above for the preparation of 2,2-dimethyl-cyclohexanone.

Sources & evidence

ORD record: ord-bd3218b3ece74055bcb848851a34a235
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07727979B2

Reaction notes

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