Amidinothiourea → HCID 178451655, compound

Reaction equation

[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=O)[CH:10](Br)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[C:16]([NH2:22])([NH2:21])=[N:17][C:18]([NH2:20])=[S:19]>>[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11]2[N:20]=[C:18]([NH:17][C:16]([NH2:22])=[NH:21])[S:19][C:10]=2[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 2724563Amidinothiourea

HCID 106839701-tert-Butyloxycarbonyl-3-bromo-4-oxopiperidine

Product 1

HCID 178451655HCID 178451655, compound

Procedure

Analogously to the preparation of Example C-01, 3-bromo-4-oxo-piperidine-1-carboxylic acid tert-butyl ester is reacted with 2-imino-4-thiobiuret to form the title compound. tR 2.55 min (LC-1); ESI-MS (+): m/z 298.25 [M+H]+.

Sources & evidence

ORD record: ord-036640b60e664529845661e0ac98e940
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07727979B2

Reaction notes

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