Water → N-(1,1,3-trimethyl-4-indanyl)-2-chloro-4-methylthiazole-5-carboxamide

Reaction equation

[CH2:25]([Cl:26])[Cl:27].[CH3:11][C:12]1([CH3:23])[CH2:13][CH:14]([CH3:22])[c:15]2[c:16]([NH2:21])[cH:17][cH:18][cH:19][c:20]21.[Cl:1][c:2]1[s:3][c:4]([C:8](=[O:9])[OH:10])[c:5]([CH3:7])[n:6]1.[OH2:24]>>[Cl:1][c:2]1[s:3][c:4]([C:8](=[O:10])[NH:21][c:16]2[c:15]3[c:20]([cH:19][cH:18][cH:17]2)[C:12]([CH3:11])([CH3:23])[CH2:13][CH:14]3[CH3:22])[c:5]([CH3:7])[n:6]1

Participants

Reactant 4

HCID 962Water

HCID 6344Dichloromethane

HCID 6669602-Chloro-4-methyl-1,3-thiazole-5-carboxylic acid

HCID 112175411,1,3-Trimethylindan-4-amine

Product 1

HCID 14535768N-(1,1,3-trimethyl-4-indanyl)-2-chloro-4-methylthiazole-5-carboxamide

Sources & evidence

ORD record: ord-a229396d3d3749db94141c82e5ca0dbe
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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