Acetate → Methyl 2-(isoquinolin-7-ylamino)-4-methylpentanoate

Reaction equation

[C:30]([O-:31])(=[O:32])[CH3:33].[C:35]([O-:36])(=[O:37])[CH3:38].[CH3:23][c:24]1[cH:25][cH:26][cH:27][cH:28][cH:29]1.[N+:12](=[N-:13])=[C:14]([C:15](=[O:16])[O:17][CH3:18])[CH2:19][CH:20]([CH3:21])[CH3:22].[NH2:1][c:2]1[cH:3][cH:4][c:5]2[cH:6][cH:7][n:8][cH:9][c:10]2[cH:11]1.[Rh+2:34]>>[NH:1]([c:2]1[cH:3][cH:4][c:5]2[cH:6][cH:7][n:8][cH:9][c:10]2[cH:11]1)[CH:14]([C:15](=[O:16])[O:17][CH3:18])[CH2:19][CH:20]([CH3:21])[CH3:22]

Participants

Reactant 5

HCID 175Acetate2×

HCID 1140Toluene

HCID 185497Rhodium, ion(Rh2)

HCID 14660277Isoquinolin-7-amine

HCID 713307532-Diazonio-1-methoxy-4-methylpent-1-en-1-olate

Product 1

HCID 60126917Methyl 2-(isoquinolin-7-ylamino)-4-methylpentanoate

Sources & evidence

ORD record: ord-55ff79acc5a14d1ab500b5f6c087c1ce
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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