Potassium Cation → 4-(4-Bromoindol-5-yloxy)-6-methoxy-7-(3-piperidinopropoxy)quinazoline

HRID 120900

Reaction equation

HRID 120900 reaction equation
[Br:30][c:31]1[c:32]2[cH:33][cH:34][nH:35][c:36]2[cH:37][cH:38][c:39]1[OH:40].[C:24](=[O:25])([O-:26])[O-:27].[Cl:1][c:2]1[n:3][cH:4][n:5][c:6]2[cH:7][c:8]([O:14][CH2:15][CH2:16][CH2:17][N:18]3[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[c:9]([O:12][CH3:13])[cH:10][c:11]12.[K+:28].[K+:29]>>[c:2]1([O:40][c:39]2[c:31]([Br:30])[c:32]3[cH:33][cH:34][nH:35][c:36]3[cH:37][cH:38]2)[n:3][cH:4][n:5][c:6]2[cH:7][c:8]([O:14][CH2:15][CH2:16][CH2:17][N:18]3[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]3)[c:9]([O:12][CH3:13])[cH:10][c:11]12

Participants

5

Reactant 4

HCID 813Potassium Cation2×HCID 19660Carbonate IonHCID 110021914-Chloro-6-methoxy-7-(3-(piperidin-1-YL)propoxy)quinazolineHCID 220305854-bromo-1H-Indol-5-ol

Product 1

HCID 220307204-(4-Bromoindol-5-yloxy)-6-methoxy-7-(3-piperidinopropoxy)quinazoline

Sources & evidence

ORD record
ord-d5ab9ca367f44f2ca0191c3967e4fe99
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Linked notes

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