Acetone → 1-(3,4-Difluorophenyl)-2-methylpropan-2-ol

HRID 12116

Reaction equation

HRID 12116 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][C:9]=1[F:10])[CH2:5]Br.[CH3:11][C:12]([CH3:14])=[O:13]>>[F:1][C:2]1[CH:3]=[C:4]([CH2:5][C:12]([CH3:14])([OH:13])[CH3:11])[CH:7]=[CH:8][C:9]=1[F:10]

Participants

3

Reactant 2

HCID 180AcetoneHCID 5814364-(Bromomethyl)-1,2-difluorobenzene

Product 1

HCID 217444631-(3,4-Difluorophenyl)-2-methylpropan-2-ol

Procedure

From 23.0 g (111 mmol) of 3,4-difluorobenzyl bromide a Grignard is prepared, which is then reacted with 11.6 mL (158 mmol) of acetone. Slightly yellow oil. Yield: 9.7 g (47%); Rf value: 0.55 (ethyl acetate-petroleum ether (1:3)).

Sources & evidence

ORD record
ord-72dec086166f4873afdcae84023e3b58
Source dataset
uspto-grants-2010_06
Patent number
US07727984B2

Linked notes

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