Potassium Cation → N-[(2,4-dichlorophenyl)methyl]-1-[4-(trifluoromethyl)pyrimidin-2-yl]pyrrolidin-3-amine

Reaction equation

[C:27](=[O:28])([O-:29])[O-:30].[Cl:16][c:17]1[n:18][cH:19][cH:20][c:21]([C:23]([F:24])([F:25])[F:26])[n:22]1.[Cl:1][c:2]1[c:3]([CH2:4][NH:5][CH:6]2[CH2:7][NH:8][CH2:9][CH2:10]2)[cH:11][cH:12][c:13]([Cl:15])[cH:14]1.[K+:31].[K+:32]>>[Cl:1][c:2]1[c:3]([CH2:4][NH:5][CH:6]2[CH2:7][N:8]([c:17]3[n:18][cH:19][cH:20][c:21]([C:23]([F:24])([F:25])[F:26])[n:22]3)[CH2:9][CH2:10]2)[cH:11][cH:12][c:13]([Cl:15])[cH:14]1

Participants

Reactant 4

HCID 813Potassium Cation2×

HCID 19660Carbonate Ion

HCID 27739122-Chloro-4-(trifluoromethyl)pyrimidine

HCID 60137425N-[(2,4-dichlorophenyl)methyl]pyrrolidin-3-amine

Product 1

HCID 66855448N-[(2,4-dichlorophenyl)methyl]-1-[4-(trifluoromethyl)pyrimidin-2-yl]pyrrolidin-3-amine

Sources & evidence

ORD record: ord-91bb277866194aabb4f33b44766207d9
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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