Acetate → 3-(2-aminopyrimidin-5-yl)-N-methyl-N-[(1-methylpyrrolo[2,3-b]pyridin-3-yl)methyl]prop-2-enamide

HRID 121351Notes

Reaction equation

HRID 121351 reaction equation
[C:26](#[N:27])[CH2:28][CH3:29].[CH3:9][N:10]([C:11]([CH:12]=[CH2:13])=[O:14])[CH2:15][c:16]1[cH:17][n:18]([CH3:25])[c:19]2[n:20][cH:21][cH:22][cH:23][c:24]12.[NH2:1][c:2]1[n:3][cH:4][c:5]([Br:8])[cH:6][n:7]1.[O-:31][C:32]([CH3:33])=[O:34].[O-:35][C:36]([CH3:37])=[O:38].[Pd+2:30]>>[NH2:1][c:2]1[n:3][cH:4][c:5]([CH:13]=[CH:12][C:11]([N:10]([CH3:9])[CH2:15][c:16]2[cH:17][n:18]([CH3:25])[c:19]3[n:20][cH:21][cH:22][cH:23][c:24]23)=[O:14])[cH:6][n:7]1

Participants

6

Reactant 5

HCID 175Acetate2×HCID 7854PropionitrileHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 2313102-Amino-5-bromopyrimidineHCID 22139100N-methyl-N-(1-methyl-1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)acrylamide

Product 1

HCID 669051483-(2-aminopyrimidin-5-yl)-N-methyl-N-[(1-methylpyrrolo[2,3-b]pyridin-3-yl)methyl]prop-2-enamide

Sources & evidence

ORD record
ord-dd098bfe9fb54a3d876c76f5f416f8c6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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