Methanol → 4-Chloro-2-[(3-chloro-2-fluorobenzyl)thio]-6-methoxypyrimidine

Reaction equation

[CH3:21][OH:22].[Cl:1][c:2]1[n:3][c:4]([S:9][CH2:10][c:11]2[c:12]([F:18])[c:13]([Cl:17])[cH:14][cH:15][cH:16]2)[n:5][c:6]([Cl:8])[cH:7]1.[H-:19].[Na+:20]>>[Cl:1][c:2]1[n:3][c:4]([S:9][CH2:10][c:11]2[c:12]([F:18])[c:13]([Cl:17])[cH:14][cH:15][cH:16]2)[n:5][c:6]([O:22][CH3:21])[cH:7]1

Participants

Reactant 4

HCID 887Methanol

HCID 923Sodium Ion

HCID 166653Hydride

HCID 859280174,6-Dichloro-2-[(3-chloro-2-fluorobenzyl)thio]pyrimidine

Product 1

HCID 866198894-Chloro-2-[(3-chloro-2-fluorobenzyl)thio]-6-methoxypyrimidine

Sources & evidence

ORD record: ord-4c6124e73cf046ab8bd037b71e0e1e78
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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