Benzene → Deschloro Loratadine

Reaction equation

[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[Cl:6].[CH3:7][N:8]1[CH2:9][CH2:10][C:11](=[C:14]2[c:15]3[c:16]([cH:25][cH:26][cH:27][cH:28]3)[CH2:17][CH2:18][c:19]3[c:20]2[n:21][cH:22][cH:23][cH:24]3)[CH2:12][CH2:13]1.[OH2:29].[cH:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[N:8]1[CH2:9][CH2:10][C:11](=[C:14]2[c:15]3[c:16]([cH:25][cH:26][cH:27][cH:28]3)[CH2:17][CH2:18][c:19]3[c:20]2[n:21][cH:22][cH:23][cH:24]3)[CH2:12][CH2:13]1

Participants

Reactant 4

HCID 241Benzene

HCID 962Water

HCID 10928Ethyl chloroformate

HCID 19861Azatadine

Product 1

HCID 12884174Deschloro Loratadine

Sources & evidence

ORD record: ord-a230bdfed0264721be1c95213d38ad5f
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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