Ammonia → N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(tetrahydro-3-furanyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

Reaction equation

[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:18]3[c:19]([F:36])[c:20]([NH:24][S:25](=[O:26])(=[O:27])[c:28]4[c:29]([F:35])[cH:30][cH:31][cH:32][c:33]4[F:34])[cH:21][cH:22][cH:23]3)[n:10][c:11]([CH:13]3[CH2:14][O:15][CH2:16][CH2:17]3)[s:12]2)[n:7]1.[NH3:37]>>[c:2]1([NH2:37])[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:18]3[c:19]([F:36])[c:20]([NH:24][S:25](=[O:26])(=[O:27])[c:28]4[c:29]([F:35])[cH:30][cH:31][cH:32][c:33]4[F:34])[cH:21][cH:22][cH:23]3)[n:10][c:11]([CH:13]3[CH2:14][O:15][CH2:16][CH2:17]3)[s:12]2)[n:7]1

Participants

Reactant 2

HCID 222Ammonia

HCID 57990020N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(tetrahydro-3-furanyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

Product 1

HCID 57989761N-{3-[5-(2-Amino-4-pyrimidinyl)-2-(tetrahydro-3-furanyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

Sources & evidence

ORD record: ord-a55ac61cf3c6427d96d1ed1c70bc7470
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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