2-Chloronicotinic acid → 2-chloro-N-[6-chloro-7-(4-methyl-piperazin-1-yl)-9H-beta-carbolin-8-yl]-nicotinamide

HRID 12186

Reaction equation

HRID 12186 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[C:13]([NH2:22])[C:14]=1[N:15]1[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]1)[NH:11][C:10]1[CH:9]=[N:8][CH:7]=[CH:6][C:5]2=1.[Cl:23][C:24]1[N:32]=[CH:31][CH:30]=[CH:29][C:25]=1[C:26](O)=[O:27]>>[Cl:23][C:24]1[N:32]=[CH:31][CH:30]=[CH:29][C:25]=1[C:26]([NH:22][C:13]1[C:14]([N:15]2[CH2:20][CH2:19][N:18]([CH3:21])[CH2:17][CH2:16]2)=[C:2]([Cl:1])[CH:3]=[C:4]2[C:12]=1[NH:11][C:10]1[CH:9]=[N:8][CH:7]=[CH:6][C:5]2=1)=[O:27]

Participants

3

Reactant 2

HCID 762582-Chloronicotinic acidHCID 671667376-chloro-7-(4-methyl-piperazin-1-yl)-8-amino-9H-beta-carboline

Product 1

HCID 113400222-chloro-N-[6-chloro-7-(4-methyl-piperazin-1-yl)-9H-beta-carbolin-8-yl]-nicotinamideYield 25%

Procedure

The desired compound was prepared according to Method A from 6-chloro-7-(4-methyl-piperazin-1-yl)-8-amino-9H-β-carboline and 2-chloro-nicotinic acid in 25% yield.

Sources & evidence

ORD record
ord-e81169359fb94455a9946173265fc171
Source dataset
uspto-grants-2010_06
Patent number
US07727985B2

Linked notes

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