6-Chloro-9H-beta-carbolin-8-amine → 1,2,2-trimethyl-5-oxo-pyrrolidine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide

HRID 12187

Reaction equation

HRID 12187 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[C:13]([NH2:15])[CH:14]=1)[NH:11][C:10]1[CH:9]=[N:8][CH:7]=[CH:6][C:5]2=1.[CH3:16][N:17]1[C:21](=[O:22])[CH2:20][CH:19]([C:23](O)=[O:24])[C:18]1([CH3:27])[CH3:26]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[C:13]([NH:15][C:23]([CH:19]3[CH2:20][C:21](=[O:22])[N:17]([CH3:16])[C:18]3([CH3:27])[CH3:26])=[O:24])[CH:14]=1)[NH:11][C:10]1[CH:9]=[N:8][CH:7]=[CH:6][C:5]2=1

Participants

3

Reactant 2

HCID 213627016-Chloro-9H-beta-carbolin-8-amineHCID 567377631,2,2-Trimethyl-5-oxopyrrolidine-3-carboxylic acid

Product 1

HCID 114515461,2,2-trimethyl-5-oxo-pyrrolidine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amideYield 68%

Procedure

The desired compound was prepared according to Method B from 6-chloro-9H-β-carboline-8-ylamine and 1,2,2-trimethyl-5-oxo-pyrrolidine-3-carboxylic acid in 68% yield.

Sources & evidence

ORD record
ord-893383a6f6244cf79604ae38fdab3519
Source dataset
uspto-grants-2010_06
Patent number
US07727985B2

Linked notes

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