6-Chloro-9H-beta-carbolin-8-amine → 4,6,6-trimethyl-morpholine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amide

HRID 12193

Reaction equation

HRID 12193 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[C:13]([NH2:15])[CH:14]=1)[NH:11][C:10]1[CH:9]=[N:8][CH:7]=[CH:6][C:5]2=1.[CH3:16][N:17]1[CH2:22][C:21]([CH3:24])([CH3:23])[O:20][CH2:19][CH:18]1[C:25](O)=[O:26]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:12](=[C:13]([NH:15][C:25]([CH:18]3[CH2:19][O:20][C:21]([CH3:23])([CH3:24])[CH2:22][N:17]3[CH3:16])=[O:26])[CH:14]=1)[NH:11][C:10]1[CH:9]=[N:8][CH:7]=[CH:6][C:5]2=1

Participants

3

Reactant 2

HCID 213627016-Chloro-9H-beta-carbolin-8-amineHCID 671654624,6,6-Trimethylmorpholine-3-carboxylic acid

Product 1

HCID 671669874,6,6-trimethyl-morpholine-3-carboxylic acid (6-chloro-9H-beta-carbolin-8-yl)-amideYield 61%

Procedure

The desired compound was prepared according to Method B from 6-chloro-9H-β-carboline-8-ylamine and 4,6,6-trimethyl-morpholine-3-carboxylic acid in 61% yield.

Sources & evidence

ORD record
ord-7af62963344d437cb6f1e896ba44c546
Source dataset
uspto-grants-2010_06
Patent number
US07727985B2

Linked notes

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