2-Phenylpiperazine → (RS)-3-ethoxycarbonyl-7-fluoro-1-methyl-4-oxo-8-(3-phenyl-1-piperazinyl)-1,4-dihydrobenzo[b][1,8]naphthyridine

Reaction equation

[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[c:7](=[O:23])[c:8]2[cH:9][c:10]3[c:11]([n:12][c:13]2[n:14]([CH3:16])[cH:15]1)[cH:17][c:18]([F:22])[c:19]([F:21])[cH:20]3.[c:24]1([CH:30]2[NH:31][CH2:32][CH2:33][NH:34][CH2:35]2)[cH:25][cH:26][cH:27][cH:28][cH:29]1>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[c:7](=[O:23])[c:8]2[cH:9][c:10]3[c:11]([n:12][c:13]2[n:14]([CH3:16])[cH:15]1)[cH:17][c:18]([N:34]1[CH2:33][CH2:32][NH:31][CH:30]([c:24]2[cH:25][cH:26][cH:27][cH:28][cH:29]2)[CH2:35]1)[c:19]([F:21])[cH:20]3

Participants

Reactant 2

HCID 2506732-Phenylpiperazine

HCID 98399873-Ethoxycarbonyl-7,8-difluoro-1-methyl-4-oxo-1,4-dihydrobenzo[b][1,8]naphthyridine

Product 1

HCID 53735832(RS)-3-ethoxycarbonyl-7-fluoro-1-methyl-4-oxo-8-(3-phenyl-1-piperazinyl)-1,4-dihydrobenzo[b][1,8]naphthyridine

Sources & evidence

ORD record: ord-9b714e4b9c9f419895087ae13ccd7733
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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