1,4-Dioxane → 4-(1-((7-morpholino-5-(1H-pyrrolo[2,3-c]pyridin-4-yl)thiazolo[5,4-d]pyrimidin-2-yl)methyl)azetidin-3-yl)morpholine

HRID 1220903

Reaction equation

HRID 1220903 reaction equation
[Br:40][c:41]1[c:42]2[c:43]([cH:44][n:45][cH:46]1)[nH:47][cH:48][cH:49]2.[CH2:50]1[O:51][CH2:52][CH2:53][O:54][CH2:55]1.[Cu+:64].[O:1]1[CH2:2][CH2:3][N:4]([c:7]2[c:8]3[c:9]([n:10][c:11]([Sn:13]([CH2:14][CH2:15][CH2:16][CH3:17])([CH2:18][CH2:19][CH2:20][CH3:21])[CH2:22][CH2:23][CH2:24][CH3:25])[n:12]2)[s:26][c:27]([CH2:29][N:30]2[CH2:31][CH:32]([N:34]4[CH2:35][CH2:36][O:37][CH2:38][CH2:39]4)[CH2:33]2)[n:28]3)[CH2:5][CH2:6]1.[s:56]1[cH:57][cH:58][cH:59][c:60]1[C:61]([O-:62])=[O:63]>>[O:1]1[CH2:2][CH2:3][N:4]([c:7]2[c:8]3[c:9]([n:10][c:11](-[c:41]4[c:42]5[c:43]([cH:44][n:45][cH:46]4)[nH:47][cH:48][cH:49]5)[n:12]2)[s:26][c:27]([CH2:29][N:30]2[CH2:31][CH:32]([N:34]4[CH2:35][CH2:36][O:37][CH2:38][CH2:39]4)[CH2:33]2)[n:28]3)[CH2:5][CH2:6]1

Participants

6

Reactant 5

HCID 312751,4-DioxaneHCID 104815Copper(1+)HCID 5017639Thiophene-2-carboxylateHCID 125100554-Bromo-1H-pyrrolo(2,3-c)pyridineHCID 596060507-Morpholin-4-yl-2-(3-morpholin-4-ylazetidin-1-ylmethyl)-5-(tributylstannanyl)thiazolo[5,4-d]pyrimidine

Product 1

HCID 596058854-(1-((7-morpholino-5-(1H-pyrrolo[2,3-c]pyridin-4-yl)thiazolo[5,4-d]pyrimidin-2-yl)methyl)azetidin-3-yl)morpholine

Sources & evidence

ORD record
ord-37134f1a1e6747058db2932a973a92f8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (5/10)

Linked notes

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