Sodium Ion → 2-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]-5-ethynylpyrimidine

Reaction equation

[Br:1][c:2]1[c:3]([O:4][CH:5]2[CH2:6][CH2:7][N:8]([c:11]3[n:12][cH:13][c:14]([C:17]#[C:18][C:19]([CH3:20])([OH:21])[CH3:22])[cH:15][n:16]3)[CH2:9][CH2:10]2)[cH:23][c:24]([F:27])[cH:25][cH:26]1.[CH3:30][c:31]1[cH:32][cH:33][cH:34][cH:35][cH:36]1.[H-:28].[Na+:29]>>[Br:1][c:2]1[c:3]([O:4][CH:5]2[CH2:6][CH2:7][N:8]([c:11]3[n:12][cH:13][c:14]([C:17]#[CH:18])[cH:15][n:16]3)[CH2:9][CH2:10]2)[cH:23][c:24]([F:27])[cH:25][cH:26]1

Participants

Reactant 4

HCID 923Sodium Ion

HCID 1140Toluene

HCID 166653Hydride

HCID 68818392HCID 68818392, compound

Product 1

HCID 866218082-[4-(2-Bromo-5-fluorophenoxy)piperidin-1-yl]-5-ethynylpyrimidine

Sources & evidence

ORD record: ord-4c18310bcecd49429ffb7116685c2d54
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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