4-[(4-Fluorophenyl)methyl]piperidin-4-ol → 2-Chloro-1-[4-(4-fluoro-benzyl)-4-hydroxy-piperidin-1-yl]-ethanone
Reaction equation
[Cl:16][CH2:17][C:18](=[O:19])[N:20]1[CH2:21][C:22](=[O:23])[N:24]([c:25]2[cH:26][cH:27][cH:28][c:29]([Cl:30])[c:31]2[CH3:32])[CH2:33]1.[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][C:7]2([OH:13])[CH2:8][CH2:9][NH:10][CH2:11][CH2:12]2)[cH:14][cH:15]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][C:7]2([OH:13])[CH2:8][CH2:9][N:10]([C:18]([CH2:17][Cl:16])=[O:19])[CH2:11][CH2:12]2)[cH:14][cH:15]1Participants
3
Sources & evidence
- ORD record
- ord-e31d5639709f4f3fb5e1a21c659ff907
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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