2,4,4-Trimethyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester → methyl 1-[4-chloro-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-1,3,5-triazin-2-yl]-2,4,4-trimethylpyrrolidine-2-carboxylate

Reaction equation

[CH3:18][C:19]1([C:33](=[O:34])[O:35][CH3:36])[N:20]([C:26]([O:27][C:28]([CH3:29])([CH3:30])[CH3:31])=[O:32])[CH2:21][C:22]([CH3:24])([CH3:25])[CH2:23]1.[Cl:1][c:2]1[n:3][c:4]([NH:9][c:10]2[cH:11][c:12]([CH:15]3[CH2:16][CH2:17]3)[n:13][nH:14]2)[n:5][c:6]([Cl:8])[n:7]1.[Cl:37][c:38]1[n:39][c:40]([NH:41][c:42]2[nH:43][n:44][c:45]([CH:46]3[CH2:47][CH2:48]3)[cH:49]2)[n:50][c:51]([N:52]2[CH2:53][CH2:54][CH2:55][C:56]2([CH3:57])[C:58]([NH:59][c:60]2[cH:61][n:62][c:63]([F:64])[cH:65][cH:66]2)=[O:67])[n:68]1>>[c:2]1([N:20]2[C:19]([CH3:18])([C:33](=[O:34])[O:35][CH3:36])[CH2:23][C:22]([CH3:24])([CH3:25])[CH2:21]2)[n:3][c:4]([NH:9][c:10]2[cH:11][c:12]([CH:15]3[CH2:16][CH2:17]3)[nH:13][n:14]2)[n:5][c:6]([Cl:8])[n:7]1