Cyclopropanesulfonyl chloride → (5RS,6RS)-8-Cyclopropanesulfonyl-6-hydroxy-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one
Reaction equation
[CH:24]1([S:27](=[O:28])(=[O:29])[Cl:30])[CH2:25][CH2:26]1.[OH:1][CH:2]1[C:3]2([CH2:4][CH2:5][N:6]([c:9]3[cH:10][cH:11][c:12]([O:15][C:16]([F:17])([F:18])[F:19])[cH:13][cH:14]3)[C:7]2=[O:8])[CH2:20][CH2:21][NH:22][CH2:23]1>>[OH:1][CH:2]1[C:3]2([CH2:4][CH2:5][N:6]([c:9]3[cH:10][cH:11][c:12]([O:15][C:16]([F:17])([F:18])[F:19])[cH:13][cH:14]3)[C:7]2=[O:8])[CH2:20][CH2:21][N:22]([S:27]([CH:24]2[CH2:25][CH2:26]2)(=[O:28])=[O:29])[CH2:23]1Participants
3
Sources & evidence
- ORD record
- ord-d063a76f614449f68e1cee7a35cc2230
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (5/10)
Reaction notes
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