Methanol → Tert-butyl 3-[(3-chloro-2-fluorophenyl)-(2-hydroxyethoxy)methyl]piperidine-1-carboxylate

Reaction equation

[BH4-:30].[CH3:32][OH:33].[Cl:1][c:2]1[c:3]([F:29])[c:4]([CH:8]([CH:9]2[CH2:10][N:11]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:12][CH2:13][CH2:14]2)[O:22][CH2:23][C:24](=[O:25])[O:26][CH2:27][CH3:28])[cH:5][cH:6][cH:7]1.[Na+:31]>>[Cl:1][c:2]1[c:3]([F:29])[c:4]([CH:8]([CH:9]2[CH2:10][N:11]([C:15](=[O:16])[O:17][C:18]([CH3:19])([CH3:20])[CH3:21])[CH2:12][CH2:13][CH2:14]2)[O:22][CH2:23][CH2:24][OH:25])[cH:5][cH:6][cH:7]1

Participants

Reactant 4

HCID 887Methanol

HCID 923Sodium Ion

HCID 28123Borohydride

HCID 67189280Tert-butyl 3-[(3-chloro-2-fluorophenyl)-(2-ethoxy-2-oxoethoxy)methyl]piperidine-1-carboxylate

Product 1

HCID 67191107Tert-butyl 3-[(3-chloro-2-fluorophenyl)-(2-hydroxyethoxy)methyl]piperidine-1-carboxylate

Sources & evidence

ORD record: ord-c62542dde4eb4d19bfd31ea46945a2d4
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

Loading…