Dimethyl Sulfoxide → 5-bromo-2-(2-methoxyethyl)-3,4-dihydroisoquinolin-1(2H)-one

Reaction equation

[Br:1][c:2]1[c:3]2[c:8]([cH:9][cH:10][cH:11]1)[C:7](=[O:12])[N:6]([CH2:13][CH2:14][OH:15])[CH2:5][CH2:4]2.[CH2:25]([O:26][CH2:27][CH3:28])[CH3:29].[CH3:21][S:22]([CH3:23])=[O:24].[I:18][CH3:19].[K+:17].[OH-:16].[OH2:20]>>[Br:1][c:2]1[c:3]2[c:8]([cH:9][cH:10][cH:11]1)[C:7](=[O:12])[N:6]([CH2:13][CH2:14][O:15][CH3:19])[CH2:5][CH2:4]2

Participants

Reactant 7

HCID 679Dimethyl Sulfoxide

HCID 813Potassium Cation

HCID 961Hydroxide

HCID 962Water

HCID 3283Diethyl Ether

HCID 6328Methyl iodide

HCID 684736355-bromo-2-(2-hydroxyethyl)-3,4-dihydroisoquinolin-1(2H)-one

Product 1

HCID 218654715-bromo-2-(2-methoxyethyl)-3,4-dihydroisoquinolin-1(2H)-one

Sources & evidence

ORD record: ord-b25e93deb55249f994f2496f7a83dab8
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (5/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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