Alpha-Aminobutyric Acid → 2-(Acetylamino)butanoic acid

HRID 1241487

Reaction equation

HRID 1241487 reaction equation
[NH2:1][CH:2]([CH2:6][CH3:7])[C:3]([OH:5])=[O:4].[C:8](OC(=O)C)(=[O:10])[CH3:9]>C(O)(=O)C>[C:8]([NH:1][CH:2]([CH2:6][CH3:7])[C:3]([OH:5])=[O:4])(=[O:10])[CH3:9]

Participants

4

Reactant 2

HCID 6657Alpha-Aminobutyric AcidHCID 7918Acetic Anhydride

Product 1

HCID 3061072-(Acetylamino)butanoic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
100 °C

Procedure

163 g (1.58 mol) 2-aminobutanoic acid are dissolved in acetic acid, and 242 g (2.37 mol) acetic anhydride are added dropwise. The mixture is stirred for 2 h at 100° C. until completion of reaction, then the solution evaporated to dryness in vacuo. The solid residue is suspended in ethyl acetate, filtered and washed with diethyl ether.

Workup

  1. customthe solution evaporated to dryness in vacuo
  2. filtrationfiltered
  3. washwashed with diethyl ether

Sources & evidence

ORD record
ord-1f439a35aca34f5790b48824d706b12d
Source dataset
uspto-grants-2006_10
Patent number
US07115602B2

Linked notes

Loading…