Acetyl chloride → Methyl 2-(2-iodophenyl)acetate

HRID 1242809

Reaction equation

HRID 1242809 reaction equation
[I:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=[O:10].[C:12](Cl)(=O)C>CO>[CH3:12][O:10][C:9](=[O:11])[CH2:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[I:1]

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 27800902-Iodophenylacetic acid

Product 1

HCID 640185Methyl 2-(2-iodophenyl)acetateYield 100%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-Iodophenylacetic acid (1.45 g) was added to a mixture of methanol (100 mL) and acetyl chloride (5 mL). After stirring at room temperature for 3 hours, the solvent was removed and the residue was dried under vacuum giving the desired 2-iodophenylacetic acid methyl ester. Yield=100%

Workup

  1. customthe solvent was removed
  2. customthe residue was dried under vacuum

Sources & evidence

ORD record
ord-9648dbe8a0734f798b9e731b9c3a0a62
Source dataset
uspto-grants-2006_10
Patent number
US07115741B2

Linked notes

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