Hydrogen chloride-ethyl acetate → HCID 21939974, compound
Reaction equation
C(OCC)(=O)C.Cl.[Cl:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([C:21]([NH:23][C:24]3[CH:29]=[CH:28][C:27]([CH:30]([OH:44])[CH:31]4[CH2:36][CH2:35][CH2:34][N:33](C(OC(C)(C)C)=O)[CH2:32]4)=[CH:26][CH:25]=3)=[O:22])=[CH:17][CH:16]=2)=[CH:11][CH:10]=1>>[ClH:8].[Cl:8][C:9]1[CH:10]=[CH:11][C:12]([C:15]2[CH:16]=[CH:17][C:18]([C:21]([NH:23][C:24]3[CH:29]=[CH:28][C:27]([CH:30]([OH:44])[CH:31]4[CH2:36][CH2:35][CH2:34][NH:33][CH2:32]4)=[CH:26][CH:25]=3)=[O:22])=[CH:19][CH:20]=2)=[CH:13][CH:14]=1Participants
3
Procedure
4N Hydrogen chloride-ethyl acetate (1 ml) was added to tert-butyl 3-[[4-[[(4′-chloro[1,1′-biphenyl]-4-yl)carbonyl]amino]phenyl](hydroxy)methyl]-1-piperidinecarboxylate (100 mg, 0.192 mmol) obtained in Reference Example 78. One hour later, the solvent was distilled out under reduced pressure. Diisopropyl ether was added to the residue, to give the titled compound (79.8 mg) as a colorless powder.
Workup
- customobtained in Reference Example 78
- distillationOne hour later, the solvent was distilled out under reduced pressure
- addition